Research Associate - Next-Gen RNA Therapeutics, UBC Vancouver

About this opportunity

UBC jobs offer exciting career paths, and the Michael Smith Laboratories at the University of British Columbia in Vancouver, Canada, is currently inviting applications for a Research Associate position in Next-Generation RNA Therapeutics. This is a unique opportunity to join a dynamic and multidisciplinary team under the supervision of Dr. Anna Blakney. The successful candidate will become an integral part of the Blakney Lab, a leading research group dedicated to advancing next-generation RNA-based vaccines and therapies. The lab's focus includes a mechanistic understanding of cellular and tissue responses to therapeutic interventions, contributing to high-impact translational projects at the interface of RNA medicines, metabolism, and regenerative biology. This role represents a significant contribution to UBC careers in cutting-edge research.

What you'll do

This research project will delve into mitochondrial metabolism, cellular bioenergetics, and tissue-level adaptation, which are increasingly recognized as central to therapeutic efficacy in regenerative medicine and immune modulation. As a Research Associate, you will be instrumental in driving this critical research forward.

• Develop and optimize in vitro and in vivo models for studying mitochondrial dynamics and cellular response to RNA formulations.
• Investigate the role of metabolic and redox signalling pathways in regulating cell fate, immune responses, and functional recovery.
• Apply advanced imaging techniques such as confocal microscopy and fluorescence lifetime imaging along with bioenergetic profiling methods including OCR, ECAR, ROS, and membrane potential measurements to evaluate therapeutic effects.
• Explore how RNA-based therapies can be integrated with photobiomodulation and metabolic modulation strategies.
• Directly inform the design of RNA medicines by linking molecular regulation of energy metabolism to functional outcomes in pre-clinical models.

Skills and experience

The ideal candidate for this Research Associate position will possess a strong academic background and a proven track record in relevant scientific fields, demonstrating leadership in research and project management.

• Hold a PhD in biophysics, biochemistry, molecular biology, or a related biomedical science.
• Possess an outstanding publication record.
• Bring advanced expertise in pre-clinical model development, including in vitro systems and rodent studies.
• Have strong experience in mitochondrial assays.
• Demonstrate strong experience in advanced imaging techniques.
• Be proficient in angiogenesis and tissue regeneration methods.
• Possess strong experience in molecular approaches to studying cellular adaptation.
• Show evidence of translational research impact, including patent drafting, grant writing, and the ability to bridge discovery research with therapeutic applications.
• Demonstrate leadership in mentoring trainees and managing interdisciplinary projects.
• Be a creative, collaborative scientist with excellent interpersonal and communication skills.

Compensation and perks

The expected pay for this Research Associate position is $80,764 per year. This opportunity at UBC offers a vibrant, collaborative environment within the Michael Smith Laboratories. You will benefit from engaging with world-class researchers in nanomedicine and gene delivery, with opportunities to grow your career and collaborate with leaders in the field through the Nanomedicine Innovation Network. This role is a valuable addition to jobs in UBC Vancouver Campus - Vancouver.

Application Process

Interested applicants for this UBC Research Associate role should submit a comprehensive CV and a cover letter detailing their experience. Please also provide contact details for three references. Application materials must be submitted via the UBC Careers portal no later than the posting end date of August 30, 2026. The appointment will be for one year commencing February 1, 2027, with a possibility for extension, subject to satisfactory performance and funding.